Serum and Tissue Expression Levels of Leptin and Leptin Receptor Are Putative Markers of Specific Feline Mammary Carcinoma Subtypes
نویسندگان
چکیده
Obesity is an established risk factor for breast cancer in post-menopausal women, being associated with elevated serum levels of leptin. Although overweight a common condition cat, the role leptin and its receptor feline mammary carcinoma remains unsettled. In this study, (ObR) were investigated 58 cats compared those healthy animals, as expression ObR tumor tissues. The results showed that Free Leptin Index significantly decreased ( p = 0.0006), particularly luminal B HER2-positive tumors, these animals also present lower < 0.0001 0.005, respectively). Interestingly, ulcerating tumors 0.0005) shorter disease-free survival 0.0217) to above 4.17 pg/mL. contrast, found all 0.0001), 16.89 ng/mL smaller 0.0118), estrogen negative status 0.0291) increased CTLA-4 0.0056), TNF-α 0.0025), PD-1 0.0023), PD-L1 0.0002). samples, overexpressed triple-negative carcinomas 0.0046), whereas be 0.0425). Altogether, our support hypothesis can used biomarkers specific subtypes, suggests use antagonists therapeutic tool, reinforcing utility cat model.
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ژورنال
عنوان ژورنال: Frontiers in Veterinary Science
سال: 2021
ISSN: ['2297-1769']
DOI: https://doi.org/10.3389/fvets.2021.625147